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Addison_Colorado - Tuesday, February 7th, 2012 9:28 AM CST
That aside, I think that a multiple-contributor blog would give you support and provide some other perspectives. You could combine this with your ideas on coaching/ghostwriting and work with 'intern' contributors to hone their skills, see their work supplying your site, and give them the tools they need to take your philosophies and understanding out on their own tangents. It might give you a regular supply of fresh, new writers and keep things going while allowing you to step back a little. (If you did go with the intern idea, drop me a line, will you? *g*) Jessica_Oregon - Tuesday, February 7th, 2012 9:14 AM CST Good for Hannity, hammering Mc Cain. Mc Cain off as so slimey. He completely bought into the Obama narrative and talks about the great calamity to come if there is no agreement, and continues to blast the Tea Party. Andrea_Minnesota - Tuesday, February 7th, 2012 8:52 AM CST It would also make it a lot harder for bullying to take place, since anyone stupid enough to try it would be taking on a potentially even bigger community, as well as whoever happened to be hosting you. (Anyone who did host would have your back 100% and be able to manage comment moderation and such so you'd never even have to see the garbage.) cepppomncx - Tuesday, February 7th, 2012 8:32 AM CST long year acer trends show only 001 more acelenolysunci topics now pr72 in 2012 Angelina_New_Jersey - Tuesday, February 7th, 2012 8:23 AM CST Having said all of that, I wonder if Ande's idea isn't the best (regardless of what format you choose to go with for the blog). If it was still public with no comments, but you cross-posted entries in a private forum, you could allow people to respond and discuss in a controlled/private environment, but still keep the blog itself public. I'm not sure how much extra work that would be for you, but if it was negligible I would say that's the best option for running your site the way you have and seem to love, but keeping the riffraff at bay. Samantha_Alaska - Tuesday, February 7th, 2012 8:12 AM CST Good for Hannity, hammering Mc Cain. Mc Cain off as so slimey. He completely bought into the Obama narrative and talks about the great calamity to come if there is no agreement, and continues to blast the Tea Party. Mackenzie_Massachusetts - Tuesday, February 7th, 2012 7:34 AM CST I think greater interaction among groups would result (mix up the tech bloggers and the marketers and the VCs and the usability people and, hell, even the sex bloggers) ;) and really spark some awesome conversations. ejzfjnzgtv - Tuesday, February 7th, 2012 7:34 AM CST long year acer trends show only 001 more acelenolysunci topics now pr40 in 2012 plusernamem8 - Tuesday, February 7th, 2012 7:31 AM CST It's belatedly but deliberation I'd performing to manage solitary hoard here first. My firt post. My start with forum, and I'm uncommonly happy to be here. Overpriced to affirm a scarcely any people. So don't be shy. i'll evaluate not to be either. Victoria_Louisiana - Tuesday, February 7th, 2012 7:24 AM CST I think that you'd probably do well in a consulting role where you are helping companies who want to improve in the area of creating passionate users (products and websites). Your knowledge of the field is shown well by your blogging, and maybe getting out in front of people will give you more of a reason to stay passionate about this subject area (if not the blog itself). Molly_Iowa - Tuesday, February 7th, 2012 7:09 AM CST Kathy, the content you have graciously shared with us every once in a while is both inspiring and entertaining. And a blog is the perfect medium for this. A lot of the content is about your style and creative personality. Thus, I would rule out the community-based ideas. I would probably only read your stuff anyway. Madelyn_New_Jersey - Tuesday, February 7th, 2012 6:54 AM CST ould also do your (wonderful) thing around the blogosphere for a while (just not always here). Keep the juices flowing, continue to help people, foster even greater community growth, and not be an (ugh) static single target. Arianna_Ohio - Tuesday, February 7th, 2012 6:43 AM CST I do think that by working in a team, it will make it easier for you. The passion moves away from you and to the team of writers, the hate will move with it. Being a part of a groupblog would be a good solution. Trinity_Missouri - Tuesday, February 7th, 2012 6:21 AM CST Kathy, the content you have graciously shared with us every once in a while is both inspiring and entertaining. And a blog is the perfect medium for this. A lot of the content is about your style and creative personality. Thus, I would rule out the community-based ideas. I would probably only read your stuff anyway. Zoey_Ohio - Tuesday, February 7th, 2012 6:11 AM CST Kathy, the content you have graciously shared with us every once in a while is both inspiring and entertaining. And a blog is the perfect medium for this. A lot of the content is about your style and creative personality. Thus, I would rule out the community-based ideas. I would probably only read your stuff anyway. Angelina_Maryland - Tuesday, February 7th, 2012 5:53 AM CST I´m not sure what you have against "The Five". I mean, four of the five panel members are on the right. The only creep is Bob Beckel. I admit, his creepiness makes the show a bit harder to handle. But Greg Gutfeld makes up for it! I LOVE him!! Beckel will probably have a stroke or a heart attack on the show one day and they can just shove him off the stage and continue on. Abigail_Virginia - Tuesday, February 7th, 2012 5:26 AM CST Is there a way use some sort of third party forum moderation to cut through this problem? Then you could go on in whatever way you are comfortable, your forums could coninue to buzz and anyone that's up to no good would hit a brick wall (or get a call from their local authorities, as appropriate). It's just a thought. Sydney_California - Tuesday, February 7th, 2012 5:12 AM CST Only reason I voted for him was SARAH. I wasn´t even going to vote until he picked her. I had voted in every election since the late 1960?s. Payton_North_Dakota - Tuesday, February 7th, 2012 4:59 AM CST O.K. I give up. What is your beef with Gutfeld? I think he is hilarious! He is not a serious contributor, but is there for laughs. I like him. Stella_Maryland - Tuesday, February 7th, 2012 4:42 AM CST It'd be kinda like the group blog idea, but with more of a "Where in the World is Carmen Sandiego?" vibe. And who didn't love playing that? :) Genesis_Vermont - Tuesday, February 7th, 2012 4:23 AM CST It'd be kinda like the group blog idea, but with more of a "Where in the World is Carmen Sandiego?" vibe. And who didn't love playing that? :) Kimberly_New_York - Tuesday, February 7th, 2012 4:06 AM CST It makes sense about not continuing with "business as usual" — I couldn't do it, either. But I can't see ghost writing as being satisfiying for someone with as strong a voice as yours. Being an evangelist for the likes of Apple or Adobe might be cool, but would that let you continue with the stream of consciousness riffs that have obviously been satifsying for you — and been so energizing for us, your readers? Don't know. Brianna_Georgia - Tuesday, February 7th, 2012 4:05 AM CST In doing this blog and thinking about this stuff, have you ever had any ideas for what kinds of tools (software, that is) that people could use to do things like share creative ideas in groups, create customer community, etc. etc.? Maya_Kansas - Tuesday, February 7th, 2012 3:41 AM CST Having said all of that, I wonder if Ande's idea isn't the best (regardless of what format you choose to go with for the blog). If it was still public with no comments, but you cross-posted entries in a private forum, you could allow people to respond and discuss in a controlled/private environment, but still keep the blog itself public. I'm not sure how much extra work that would be for you, but if it was negligible I would say that's the best option for running your site the way you have and seem to love, but keeping the riffraff at bay. Faith_Washington - Tuesday, February 7th, 2012 3:31 AM CST I always wondered if the Manchurian Candidate – McLame – would make an appearance. I think he is a victim of Stockholm Syndrome, too. Caroline_Colorado - Tuesday, February 7th, 2012 3:12 AM CST Maybe the private blog is the way to go, though I suspect you'd need some time to get revved up for that. The pod/video angle sounds great, but that raises a lot of other questions. And it loses the immediacy that you enjoyed so long, which is one of the most unfortunate losses in all this. Jessica_Illinois - Tuesday, February 7th, 2012 2:59 AM CST O.K. I give up. What is your beef with Gutfeld? I think he is hilarious! He is not a serious contributor, but is there for laughs. I like him. Lillian_Minnesota - Tuesday, February 7th, 2012 2:36 AM CST It makes sense about not continuing with "business as usual" — I couldn't do it, either. But I can't see ghost writing as being satisfiying for someone with as strong a voice as yours. Being an evangelist for the likes of Apple or Adobe might be cool, but would that let you continue with the stream of consciousness riffs that have obviously been satifsying for you — and been so energizing for us, your readers? Don't know. qfdqczfphj - Tuesday, February 7th, 2012 2:24 AM CST long year acer trends show only 001 more acelenolysunci topics now pr59 in 2012 anicarcergy - Tuesday, February 7th, 2012 2:22 AM CST Thank you very much! ------------------------------------------------ Madelyn_Florida - Tuesday, February 7th, 2012 2:09 AM CST I was thinking the same thing about Alexa as there was quite a lot of movement. They might have readjusted their adjustment for "technology skew" - or what ever it was…. Faith_Montana - Tuesday, February 7th, 2012 1:59 AM CST It makes sense about not continuing with "business as usual" — I couldn't do it, either. But I can't see ghost writing as being satisfiying for someone with as strong a voice as yours. Being an evangelist for the likes of Apple or Adobe might be cool, but would that let you continue with the stream of consciousness riffs that have obviously been satifsying for you — and been so energizing for us, your readers? Don't know. Julia_New_York - Tuesday, February 7th, 2012 1:23 AM CST I also really enjoy the idea of a group blog mostly because I've always been a fan of group blogs a la 37signals. It's a different take on things that I tend to enjoy, getting to see different opinions, group dynamics, etc. dsrtyzdtlw - Tuesday, February 7th, 2012 1:23 AM CST long year acer trends show only 001 more acelenolysunci topics now pr54 in 2012 Caroline_Missouri - Tuesday, February 7th, 2012 1:13 AM CST I always wondered if the Manchurian Candidate – McLame – would make an appearance. I think he is a victim of Stockholm Syndrome, too. Abigail_Oklahoma - Tuesday, February 7th, 2012 12:55 AM CST I´m not sure what you have against "The Five". I mean, four of the five panel members are on the right. The only creep is Bob Beckel. I admit, his creepiness makes the show a bit harder to handle. But Greg Gutfeld makes up for it! I LOVE him!! Beckel will probably have a stroke or a heart attack on the show one day and they can just shove him off the stage and continue on. Camila_New_Jersey - Tuesday, February 7th, 2012 12:41 AM CST I understand. That is why I made the point about the state caucus to come up with acceptable Presidential candidates. My fear is we have too many conservatives that may split our vote and let a Romney, Christie get in. Khloe_Virginia - Tuesday, February 7th, 2012 12:30 AM CST In relation to the Technorati rank it´s pulled down via an API (geez I think that´s what it´s called) as is Alexa rank & the script calculates the index - I just need to record the figures in a spreadsheet for upload. Aaliyah_New_Hampshire - Tuesday, February 7th, 2012 12:10 AM CST Take me for example. I could support Bachman, Cain, Palin, or Santorum. in no particular order. Others would choose fewer plus Paul. Rachel_Oklahoma - Tuesday, February 7th, 2012 12:00 AM CST And a belated Happy Easter to you too! The fruit cakes being compared to bricks definitely makes my chuckle list…..perhaps some fruity garnish around the display would have added more relevance. It is quite strange how the human mind works, and association is key to avoid possible misyunderstandings like this one! Classic! Lily_Utah - Monday, February 6th, 2012 11:41 PM CST That aside, I think that a multiple-contributor blog would give you support and provide some other perspectives. You could combine this with your ideas on coaching/ghostwriting and work with 'intern' contributors to hone their skills, see their work supplying your site, and give them the tools they need to take your philosophies and understanding out on their own tangents. It might give you a regular supply of fresh, new writers and keep things going while allowing you to step back a little. (If you did go with the intern idea, drop me a line, will you? *g*) Lauren_Missouri - Monday, February 6th, 2012 11:16 PM CST I hate to see us lose your input but I wonder if simply publishing articles with no comments enabled and having a members-only forum wouldn't be a good compromise. There's something about the immediacy of the response form and the lack of accountability available from anonymity (oh, hypocritical me) that seems to encourage people's awfulness. pletcherpkf - Monday, February 6th, 2012 11:05 PM CST Conserved signaling pathways that activate the mitogen-activated protein kinases (MAPKs) are involved in relaying extracellular stimulations to intracellular responses. The MAPKs coordinately regulate cell proliferation, differentiation, motility, and survival, which are functions also known to be mediated by members of a growing family of MAPK-activated protein kinases (MKs; formerly known as MAPKAP kinases). The MKs are related serine/threonine kinases that respond to mitogenic and stress stimuli through proline-directed phosphorylation and activation of the kinase domain by extracellular signal-regulated kinases 1 and 2 and p38 MAPKs. There are currently 11 vertebrate MKs in five subfamilies based on primary sequence homology: the ribosomal S6 kinases, the mitogen- and stress-activated kinases, the MAPK-interacting kinases, MAPK-activated protein kinases 2 and 3, and MK5. In the last 5 years, several MK substrates have been identified, which has helped tremendously to identify the biological role of the members of this family. Together with data from the study of MK-knockout mice, the identities of the MK substrates indicate that they play important roles in diverse biological processes, including mRNA translation, cell proliferation and survival, and the nuclear genomic response to mitogens and cellular stresses. In this article, we review the existing data on the MKs and discuss their physiological functions based on recent discoveries. Cells recognize and respond to extracellular stimuli by engaging specific intracellular programs, such as the signaling cascade that leads to activation of the mitogen-activated protein kinases (MAPKs). All eukaryotic cells possess multiple MAPK pathways, which coordinately regulate diverse cellular activities running the gamut from gene expression, mitosis, and metabolism to motility, survival and apoptosis, and differentiation. To date, five distinct groups of MAPKs have been characterized in mammals: extracellular signal-regulated kinases (ERKs) 1 and 2 (ERK1/2), c-Jun amino-terminal kinases (JNKs) 1, 2, and 3, p38 isoforms ¦Á, ¦Â, ¦Ã, and¦Ä , ERKs 3 and 4, and ERK5 (reviewed in references 25 and 103). Since Saccharomyces cerevisiae possesses six different MAPKs, the relative complexity of the human genome suggests that there are probably several additional vertebrate MAPK subfamilies (118). The most extensively studied groups of vertebrate MAPKs to date are the ERK1/2, JNKs, and p38 kinases. MAPKs can be activated by a wide variety of different stimuli, but in general, ERK1 and ERK2 are preferentially activated in response to growth factors and phorbol esters, while the JNK and p38 kinases are more responsive to stress stimuli ranging from osmotic shock and ionizing radiation to cytokine stimulation (reviewed in reference 147) (Fig. 1). Although each MAPK has unique characteristics, a number of features are shared by the MAPK pathways studied to date. Each family of MAPKs is composed of a set of three evolutionarily conserved, sequentially acting kinases: a MAPK, a MAPK kinase (MAPKK), and a MAPKK kinase (MAPKKK). The MAPKKKs, which are serine/threonine kinases, are often activated through phosphorylation and/or as a result of their interaction with a small GTP-binding protein of the Ras/Rho family in response to extracellular stimuli (36, 98). MAPKKK activation leads to the phosphorylation and activation of a MAPKK, which then stimulates MAPK activity through dual phosphorylation on threonine and tyrosine residues located in the activation loop of kinase subdomain VIII. Once activated, MAPKs phosphorylate target substrates on serine or threonine residues followed by a proline; however, substrate selectivity is often conferred by specific interaction motifs located on physiological substrates. Furthermore, MAPK cascade specificity is also mediated through interaction with scaffolding proteins which organize pathways in specific modules through simultaneous binding of several components. Aaliyah_Michigan - Monday, February 6th, 2012 11:02 PM CST I see two basic options for you: Reduce visibility and do something completely different, or stay visible and continue publishing your own stuff under your own name. All the options you cite can be assigned to one of these two categories. I dearly hope you go with the second option, even though I would totally understand if you decide otherwise. Mia_Pennsylvania - Monday, February 6th, 2012 10:50 PM CST Kathy, the content you have graciously shared with us every once in a while is both inspiring and entertaining. And a blog is the perfect medium for this. A lot of the content is about your style and creative personality. Thus, I would rule out the community-based ideas. I would probably only read your stuff anyway. Caroline_Ohio - Monday, February 6th, 2012 10:32 PM CST I think greater interaction among groups would result (mix up the tech bloggers and the marketers and the VCs and the usability people and, hell, even the sex bloggers) ;) and really spark some awesome conversations. Audrey_Massachusetts - Monday, February 6th, 2012 10:16 PM CST That´s fine for the House and Senate but for president, there is no way any conservative should vote for either Democrat that will be stuffed down our throats next year. The House is the grand prize. If we had someone like Jim Jordan as Speaker and more than the current 3 reliable conservative senators, the president wouldn´t matter. Andrea_West_Virginia - Monday, February 6th, 2012 9:58 PM CST Just look at the difference just 20-30 rock solid Tea Party conservatives have made in the House already. They´ve turned "1/3 of the government" on its head and started a war between the establishment party and the Tea Party. Camila_Washington - Monday, February 6th, 2012 9:57 PM CST It makes sense about not continuing with "business as usual" — I couldn't do it, either. But I can't see ghost writing as being satisfiying for someone with as strong a voice as yours. Being an evangelist for the likes of Apple or Adobe might be cool, but would that let you continue with the stream of consciousness riffs that have obviously been satifsying for you — and been so energizing for us, your readers? Don't know. Maya_Minnesota - Monday, February 6th, 2012 9:35 PM CST I think that you'd probably do well in a consulting role where you are helping companies who want to improve in the area of creating passionate users (products and websites). Your knowledge of the field is shown well by your blogging, and maybe getting out in front of people will give you more of a reason to stay passionate about this subject area (if not the blog itself). Samantha_Kentucky - Monday, February 6th, 2012 9:24 PM CST And a belated Happy Easter to you too! The fruit cakes being compared to bricks definitely makes my chuckle list…..perhaps some fruity garnish around the display would have added more relevance. It is quite strange how the human mind works, and association is key to avoid possible misyunderstandings like this one! Classic! Natalie_Pennsylvania - Monday, February 6th, 2012 9:07 PM CST It would also make it a lot harder for bullying to take place, since anyone stupid enough to try it would be taking on a potentially even bigger community, as well as whoever happened to be hosting you. (Anyone who did host would have your back 100% and be able to manage comment moderation and such so you'd never even have to see the garbage.) Bella_Texas - Monday, February 6th, 2012 8:53 PM CST Is there a way use some sort of third party forum moderation to cut through this problem? Then you could go on in whatever way you are comfortable, your forums could coninue to buzz and anyone that's up to no good would hit a brick wall (or get a call from their local authorities, as appropriate). It's just a thought. Morgan_California - Monday, February 6th, 2012 8:32 PM CST It makes sense about not continuing with "business as usual" — I couldn't do it, either. But I can't see ghost writing as being satisfiying for someone with as strong a voice as yours. Being an evangelist for the likes of Apple or Adobe might be cool, but would that let you continue with the stream of consciousness riffs that have obviously been satifsying for you — and been so energizing for us, your readers? Don't know. Trinity_Alabama - Monday, February 6th, 2012 8:04 PM CST What is really infuriating is his denial that he was attacking the Tea Party. He was "only reading a WSJ article" on the floor of the Senate. Hannity could have done a better job of hammering on THAT giant piece of brazen hypocrisy. Kylie_Nebraska - Monday, February 6th, 2012 7:55 PM CST I do hesitate to run with the other commenters that say you should monetize this, but you should make it at least a part-time passion where you are getting to stretch out on the things you write about, and then allow experiences to craft other posts. Madelyn_Utah - Monday, February 6th, 2012 7:19 PM CST Only reason I voted for him was SARAH. I wasn´t even going to vote until he picked her. I had voted in every election since the late 1960?s. Emily_Massachusetts - Monday, February 6th, 2012 7:09 PM CST Oodles of bloggers great and small would give a #1 Technorati rank (or insert personal thing of inestimable value here) to be able to host Kathy Sierra as a guest blogger. (Myself included.) Taylor_New_Mexico - Monday, February 6th, 2012 6:50 PM CST I was thinking the same thing about Alexa as there was quite a lot of movement. They might have readjusted their adjustment for "technology skew" - or what ever it was…. Avery_Rhode_Island - Monday, February 6th, 2012 6:36 PM CST In relation to the Technorati rank it´s pulled down via an API (geez I think that´s what it´s called) as is Alexa rank & the script calculates the index - I just need to record the figures in a spreadsheet for upload. Morgan_Tennessee - Monday, February 6th, 2012 6:23 PM CST In doing this blog and thinking about this stuff, have you ever had any ideas for what kinds of tools (software, that is) that people could use to do things like share creative ideas in groups, create customer community, etc. etc.? Madeline_North_Dakota - Monday, February 6th, 2012 6:03 PM CST It´s entirely possible that I copied that individual number across incorrectly (and that the index was correct), but when I did the query just then it returned a Technorati Rank of 37, so as you say there would be no change in the rank, but an improvement in your index. Arianna_Illinois - Monday, February 6th, 2012 5:53 PM CST It makes sense about not continuing with "business as usual" — I couldn't do it, either. But I can't see ghost writing as being satisfiying for someone with as strong a voice as yours. Being an evangelist for the likes of Apple or Adobe might be cool, but would that let you continue with the stream of consciousness riffs that have obviously been satifsying for you — and been so energizing for us, your readers? Don't know. Lauren_Maine - Monday, February 6th, 2012 5:35 PM CST Kathy, the content you have graciously shared with us every once in a while is both inspiring and entertaining. And a blog is the perfect medium for this. A lot of the content is about your style and creative personality. Thus, I would rule out the community-based ideas. I would probably only read your stuff anyway. Brooklyn_Minnesota - Monday, February 6th, 2012 5:08 PM CST And a belated Happy Easter to you too! The fruit cakes being compared to bricks definitely makes my chuckle list…..perhaps some fruity garnish around the display would have added more relevance. It is quite strange how the human mind works, and association is key to avoid possible misyunderstandings like this one! Classic! Caroline_Wyoming - Monday, February 6th, 2012 4:57 PM CST It'd be kinda like the group blog idea, but with more of a "Where in the World is Carmen Sandiego?" vibe. And who didn't love playing that? :) Sydney_Nevada - Monday, February 6th, 2012 4:44 PM CST What is really infuriating is his denial that he was attacking the Tea Party. He was "only reading a WSJ article" on the floor of the Senate. Hannity could have done a better job of hammering on THAT giant piece of brazen hypocrisy. Valeria_Rhode_Island - Monday, February 6th, 2012 4:26 PM CST The reality is that the establishment in the Senate HATE CCB, modest as it really is and see the new Boehner plan as an out, since they figure they will get Reid to make a compromise since it is only 22 Billion in cuts. |